Clinicopathological Characteristics of Patients with Gastric Cancer according to the Expression of LIN28Aopen access
- Authors
- Park, Chan Hyuk; Lee, Jung Hwa; Lee, Na Keum; Lee, Yong Chan; Lee, Sang Kil
- Issue Date
- Sep-2016
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- LIN28A; Stomach neoplasms; Survival
- Citation
- GUT AND LIVER, v.10, no.5, pp.714 - 718
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- GUT AND LIVER
- Volume
- 10
- Number
- 5
- Start Page
- 714
- End Page
- 718
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4974
- DOI
- 10.5009/gnl15283
- ISSN
- 1976-2283
- Abstract
- Background/Aims
Although LIN28A is known to potentially play a role in the oncogenesis of various cancers, whether LIN28A expression is a predictor of poor prognosis in patients with gastric cancer has not been fully explored. We sought to evaluate clinicopathological characteristics according to the expression of LIN28A in numerous gastric cancer tissue samples.
Methods
LIN28A expression was evaluated by immunohistochemical (IHC) analysis of a tissue microarray comprising 288 gastric cancer tissues and 288 adjacent normal tissues. Clinicopathological characteristics, including overall survival, were compared according to LIN28A expression.
Results
The IHC staining score was lower for the cancer tissues than the normal tissues (p<0.001). However, no significant differences were observed in the clinicopathological characteristics between the low and high LIN28A expression groups. In addition, the 5-year overall survival rate did not differ between the two groups: 75.3% (95% confidence interval [CI], 69.3% to 81.7%) versus 71.6% (95% CI, 63.3% to 80.9%) for low versus high expression, respectively.
Conclusions
The expression of LIN28A did not appear to play a distinct role in predicting the clinicopathological characteristics of patients with gastric cancer. In addition, LIN28A expression was not an independently associated factor for overall survival in patients with gastric cancer.
- Files in This Item
-
- Appears in
Collections - 서울 의과대학 > 서울 내과학교실 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/4974)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.