Visceral adipose tissue macrophage-targeted TACE silencing to treat obesity-induced type 2 diabetes
- Authors
- Yong, Seok-Beom; Song, Yoonsung; Kim, Yong-Hee
- Issue Date
- Dec-2017
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Adipose tissue macrophage; Visceral adipose tissue; Anti-inflammatory gene delivery; Targeted gene delivery
- Citation
- BIOMATERIALS, v.148, pp.81 - 89
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMATERIALS
- Volume
- 148
- Start Page
- 81
- End Page
- 89
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5327
- DOI
- 10.1016/j.biomaterials.2017.09.023
- ISSN
- 0142-9612
- Abstract
- Obesity is an increasingly prevalent global health problem. Due to its close relations with metabolic diseases and cancer, new therapeutic approaches for treating obesity and obesity-induced metabolic diseases are required. Visceral white adipose tissue (WAT) has been closely associated with obesity induced inflammation and adipose tissue macrophages (ATMs) are responsible for obesity-induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6. TNF-alpha converting enzyme (TACE) is a transmembrane enzyme that induces the enzymatic cleavage and release of inflammatory cytokines. In this study, we developed a nonviral gene delivery system consisting of an oligopeptide (ATS-9R) that can selectively target visceral ATMs. In here we shows visceral adipose tissue-dominant inflammatory gene over-expressions in obese mouse and our strategy enabled the preferential delivery of therapeutic genes to visceral ATMs and successfully achieved ATM targeted gene silencing. Finally, ATS-9R-mediated TACE gene silencing in visceral ATMs alleviated visceral fat inflammation and improved type 2 diabetes by reducing whole body inflammation.
- Files in This Item
-
Go to Link
- Appears in
Collections - 서울 공과대학 > 서울 생명공학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5327)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.