EFFECTS OF IL-6 RECEPTOR INHIBITION THERAPY ON THE SERUM LEVELS OF IL-33 AND IL-6 IN PATIENTS WITH RHEUMATOID ARTHRITIS
- Authors
- Choi, I. A.; Lee, S. J.; Park, W.; Park, S. H.; Shim, S. -C.; Baek, H. J.; Yoo, D. -H.; Kim, H. A.; Lee, S. K.; Lee, Y. J.; Park, Y. E.; Cha, H. -S.; Lee, E. Y.; Lee, E. B.; Song, Y. W.
- Issue Date
- Jun-2016
- Publisher
- BMJ PUBLISHING GROUP
- Citation
- ANNALS OF THE RHEUMATIC DISEASES, v.75, pp.456 - 456
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANNALS OF THE RHEUMATIC DISEASES
- Volume
- 75
- Start Page
- 456
- End Page
- 456
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5589
- DOI
- 10.1136/annrheumdis-2016-eular.3090
- ISSN
- 0003-4967
- Abstract
- Background Several pro-inflammatory cytokines such as TNF-α, IL-1, IL-6, IL-8 and IL-15 are known to be critical in synovial inflammatory process in RA and successful results have been obtained in RA treatment with targeting pro-inflammatory cytokines including TNF-α, IL-1 and IL-6.
Objectives This study sought to investigate the role of IL-33 and IL-6 in RA patients receiving IL-6 receptor inhibition therapy.
Methods We analyzed the association of the IL-33 and IL-6 level with disease activity and serologic features in 83 patients with RA. We also measured the serum level of IL-33 and IL-6 before and after the administration of tocilizumab for 24 weeks in 40 patients.
Results Serum IL-33 level showed significant correlation with RF (rho =0.660, p<0.001) but did not correlate with DAS28, ESR, hsCRP or RA duration. IL-6 level was significantly correlated with hsCRP (rho =0.482, p<0.001) but not correlate with DAS28, ESR, RF or RA duration. There was no correlation between serum IL-6 and IL-33 levels.
Serum IL-33 level significantly decreased after 24 weeks of IL-6 receptor inhibition in patients with RA (p<0.001). When comparing subgroups according to ACR20 response, serum IL-33 levels were significantly decreased after 24 weeks of IL-6 receptor inhibition therapy in ACR20 responders (p<0.001) but not in the non-responders (p=0.084). Baseline IL-33 levels were not significantly different between the two subgroups (p=0.765).
Serum IL-6 levels were not significantly changed after 24 weeks of IL-6 receptor inhibition therapy (median 7.1 to 8.9 pg/mL, p=0.503). Changes of IL-6 levels were insignificant both in ACR20 responders and non-responders after 24 weeks of IL-6 receptor inhibition therapy. Baseline IL-6 levels were not different between ACR20 responders and non-responders.
Conclusions The use of IL-6 receptor inhibitor decreased the serum level of IL-33 and this effect seems to be led by the responder group. IL-33 could be a useful indicator to monitor the response in IL-6 receptor inhibition therapy.
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