Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation
- Authors
- Park, Dae-Hwan; Cho, Jaeyong; Kwon, Oh-Joon; Yun, Chae-Ok; Choy, Jin-Ho
- Issue Date
- Mar-2016
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- cancer therapy; inorganic nanovectors; nanoparticles; layered compounds; siRNA delivery
- Citation
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.55, no.14, pp.4582 - 4586
- Indexed
- SCIE
SCOPUS
- Journal Title
- ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Volume
- 55
- Number
- 14
- Start Page
- 4582
- End Page
- 4586
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/5640
- DOI
- 10.1002/anie.201510844
- ISSN
- 1433-7851
- Abstract
- The biodegradable inorganic nanovector based on a layered double hydroxide (LDH) holds great promise for gene and drug delivery systems. However, invivo targeted delivery of genes through LDH still remains a key challenge in the development of RNA interference therapeutics. Here, we describe invivo and invitro delivery system for Survivin siRNA (siSurvivin) assembled with passive LDH with a particle size of 100nm or active LDH conjugated with a cancer overexpressing receptor targeting ligand, folic acid (LDHFA), conferring them an ability to target the tumor by either EPR-based clathrin-mediated or folate receptor-mediated endocytosis. When not only transfected into KB cells but also injected into xenograft mice, LDHFA/siSurvivin induced potent gene silencing at mRNA and protein levels invitro, and consequently achieved a 3.0-fold higher suppression of tumor volume than LDH/siSurvivin invivo. This anti-tumor effect was attributed to a selectively 1.2-fold higher accumulation of siSurvivin in tumor tissue compared with other organs. Targeting to the tumor with inorganic nanovector can guide and accelerate an evolution of next-generation theranosis system.
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