Synthesis and antiproliferative active pyrrlol[2,3-b]pyrimidine derivative for melanoma

Abstract

Melanoma is the most aggressive form of skin cancer and is the fastest growing cancer in the United States. In this study, the synthesis of a new series of diaryl urea having pyrrlol[2,3-d]pyrimidine scaffold is described. Their in vitro antiproliferative activities against human melanoma cell line A375 were tested and the effect of substituents on the phenyl ring was investiged.