Synthetic Approach toward Novel Strained Macrolide, Pondaplin : Application of IMDA Reaction as Macrocyclization Strategy

Abstract

Pondaplin, isolated in 1999 from the leaves of Annona graba shows potent cytotoxicity against breast and prostate cancer cells. Strained ansa-chain presents a significant challenge for the total synthesis of this (9)paracyclophane natural product. Our approach toward this molecules is based on the IMDA reaction nd subsequent aromatization for the formation of macrolide. Preliminary inverstigation of Stille-transtherification-IMDA sequences is presented