Design of cell-interactive polymers for tissue regeneration

Abstract

Every year millions of patients suffer the loss or failure of an organ or tissue as a result of accidents or disease. Tissue or organ transplantation is a generally accepted therapy to treat these patients. However, this approach is extremely limited by a donor shortage. Tissue engineering is one recent and exciting strategy to treat patients who need a new organ or tissue with man-made organs or tissues. In this approach, tissues are engineered using a combination of a patient`s own cells and polymer scaffolds. Tissue-specific cells are isolated from a small biopsy from the patient and expanded in vitro. The cells are subsequently incorporated into a three-dimensionally designed polymer scaffold. The polymer scaffold potentially mimics many roles of natural extracellular matrices, which bring cells together and control the tissue structure, regulate the function of the cells, and allow the diffusion of nutrients, metabolites, and soluble factors. One critical element in this tissue engineering approach is the regulation of interactions between cells and polymer scaffolds. The interactions can be regulated by controlling specific ligand-receptor interactions, physical properties of the scaffolds (e.g., mechanical properties and degradation rate), and the release of soluble factors (e.g., growth factor and DNA) from the scaffolds. Various polymers have been studied and utilized to date in tissue engineering approaches. However, no single polymer has been considered ideal for all tissues and approaches. In this talk, design parameters of cell-interactive polymeric materials, potentially useful in tissue regeneration, will be discussed.