Preparation of silica particles encapsulating retinol in o/w/o multiple emulsion by sol-gel method

Abstract

Retinol, a cosmetic ingredient, was entrapped within inorganic microspheres obtained from sol-gel reaction of TEOS in o/w/o multiple emulsion as microreactors. In O/W/O multiple emulsions, the retinol was emulsified as an internal oil phase in an aqueous solution of 3.0 wt% Tween 20 prior to emulsification into an external oil phase. The multiple emulsion was appeared to be stable enough in the presence of HPC polymer in the external oil phase.