A pharmacokinetic evaluation of the rituximab biosimilar CT-P10 in the treatment of rheumatoid arthritis
- Authors
- Yoo, Dae Hyun; Suh, Chang-Hee; Shim, Seung Cheol; Lee, Sang Joon; Kim, Sung Hyun; Park, Won
- Issue Date
- Dec-2020
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- CT-P10; rituximab; biosimilar; rheumatoid arthritis; pharmacokinetics
- Citation
- EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY, v.16, no.12, pp.1125 - 1132
- Indexed
- SCIE
SCOPUS
- Journal Title
- EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
- Volume
- 16
- Number
- 12
- Start Page
- 1125
- End Page
- 1132
- URI
- https://scholarworks.bwise.kr/hanyang/handle/2021.sw.hanyang/8135
- DOI
- 10.1080/17425255.2020.1832082
- ISSN
- 1742-5255
- Abstract
- Introduction
CT-P10 is the first biosimilar of rituximab (RTX) for the treatment of rheumatoid arthritis (RA). The application of valuable biosimilar for the treatment of RA may decrease economic burden of society, and disease activity of RA. Thus, it is worthwhile to identify the economic advantage and further requirement for the proper use of CT-P10 in real world.
Areas covered
Literature searching was performed to identify suitable references written in English for this review article. Rituximab, biosimilar, CT-P10, and rheumatoid arthritis were used as keywords. Current state of RA treatment, position of RTX in the recommendations for the treatment of RA, current status of RTX biosimilar development were assessed before evaluating CT-P10 itself. Physicochemical property, pharmacokinetic profile through phase I to phase III studies, pharmacodynamics, toxicology data, clinical efficacy, and safety were reviewed
Expert opinion
As the first biosimilar to originator RTX, CT-P10 may be a useful alternative for the treatment of RA in all indications for originator RTX. In addition, more studies are required to identify long-term effectiveness and safety of CT-P10 in real world. It is also important to find out new indications of CT-P10 and effective mechanisms to lessen nocebo effect against biosimilar including CT-P10.
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