Detailed Information

Cited 6 time in webofscience Cited 6 time in scopus
Metadata Downloads

Esculetin induces cell cycle arrest and apoptosis in human colon cancer LoVo cells

Authors
Choi, Yong J.Lee, Chang M.Park, See-HyoungNam, Myeong J.
Issue Date
Oct-2019
Publisher
WILEY
Keywords
apoptosis; cell cycle; colon cancer cell; esculetin
Citation
ENVIRONMENTAL TOXICOLOGY, v.34, no.10, pp.1129 - 1136
Journal Title
ENVIRONMENTAL TOXICOLOGY
Volume
34
Number
10
Start Page
1129
End Page
1136
URI
https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/1082
DOI
10.1002/tox.22815
ISSN
1520-4081
Abstract
We investigated the anti-cancer effects of ESC in human colon cancer LoVo cells. Cell counting assay results showed that ESC inhibited the proliferation of LoVo cells. Cell cycle arrest results showed that cell cycle was arrested during the G0/G1 phase in the ESC-treated LoVo cells. Western blot results showed that the cell cycle inhibitory proteins p53, p27, and p21 were increased, and cyclin D1, the cell cycle progressive protein, was decreased. Sp1 is a transcription factor regulating cell proliferation, was decreased in the ESC-treated LoVo cells. Annexin V/propidium iodide staining results showed that ESC induces apoptosis in LoVo cells. Western blot results showed that Bax, cleaved caspase -3, -7, -9, and poly(ADP-ribose) polymerase, which are proapoptotic proteins, were increased and the antiapoptotic protein Bcl-2 was decreased. Taken together, ESC induced apoptosis and has an anti-cancer effect in LoVo cells.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, See Hyoung photo

Park, See Hyoung
Science & Technology (Biological and Chemical Engineering)
Read more

Altmetrics

Total Views & Downloads

BROWSE