Self-Assembly Behavior of Elastin-like Polypeptide Diblock Copolymers Containing a Charged Moiety
- Authors
- Choi, Jeong-Wan; Choi, Soo-Hyung; Won, Jong-In
- Issue Date
- Jun-2021
- Publisher
- American Chemical Society
- Citation
- Biomacromolecules, v.22, no.6, pp.2604 - 2613
- Journal Title
- Biomacromolecules
- Volume
- 22
- Number
- 6
- Start Page
- 2604
- End Page
- 2613
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/15507
- DOI
- 10.1021/acs.biomac.1c00322
- ISSN
- 1525-7797
- Abstract
- Elastin-like polypeptides (ELPs) are stimulus-responsive protein-based biopolymers, and some ELP block copolymers can assemble into spherical nanoparticles with thermosensitivity. In this study, two different ELP diblock copolymers, each composed of a hydrophobic and a charged moiety, were synthesized, and the dependence of their physical properties on pH, temperature, and salt concentration was investigated. A series of analyses revealed that hydrophobic core micelles could be generated in response to a change in their surroundings and that micelles did not self-aggregate, a phenomenon due to the repulsive forces between like-charged molecules on the surface. We also demonstrated that self-assembly behavior was closely dependent on the character of the charged amino acid and the specific anion in solution.
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Collections - College of Engineering > Chemical Engineering Major > 1. Journal Articles
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