Injectable hydrogels with improved mechanical property based on electrostatic associations
- Authors
- Choi, Jewon; Yoon, Jiwon; Ahn, Kyung Hyun; Choi, Soo-Hyung; Char, Kookheon
- Issue Date
- Mar-2021
- Publisher
- Springer Verlag
- Keywords
- Biodegradability; Block copolymer; Electrostatic association; Self-healing; Temperature-responsive hydrogel
- Citation
- Colloid and Polymer Science, v.299, no.3, pp.575 - 584
- Journal Title
- Colloid and Polymer Science
- Volume
- 299
- Number
- 3
- Start Page
- 575
- End Page
- 584
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/16157
- DOI
- 10.1007/s00396-020-04726-0
- ISSN
- 0303-402X
- Abstract
- The mechanical properties of injectable and thermo-responsive ABC triblock copolymer hydrogels are enhanced by the electrostatic attraction between oppositely charged moieties introduced in the mid-blocks. The triblock copolymers are composed of biodegradable poly(epsilon-caprolactone) (PCL), hydrophilic cationic or anionic mid-block, and temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) with quadruple hydrogen bonding units. PCL blocks and PNIPAM blocks form separate micellar cores, and the mid-blocks make a bridge between the cores. The dynamic nature and thermo-responsiveness of the PNIPAM block primarily endow the temperature- and shear-responsiveness to the hydrogel, and therefore make the hydrogel injectable and self-healable. In particular, the electrostatic attraction introduced in the mid-blocks results in the enhanced mechanical properties of the hydrogels. The dual-responsive hydrogel with the improved moduli will aid in designing soft materials in the field of biological and biomedical applications.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Engineering > Chemical Engineering Major > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.