Novel strategy for enhancing productivity in L-DOPA synthesis: The electroenzymatic approach using well-dispersed L-tyrosine
DC Field | Value | Language |
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dc.contributor.author | Min, Kyoungseon | - |
dc.contributor.author | Kathavarayan, Thenmozhi | - |
dc.contributor.author | Park, Kyungmoon | - |
dc.contributor.author | Yoo, Young Je | - |
dc.date.accessioned | 2021-11-11T04:41:19Z | - |
dc.date.available | 2021-11-11T04:41:19Z | - |
dc.date.created | 2021-11-10 | - |
dc.date.issued | 2013-06 | - |
dc.identifier.issn | 1381-1177 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/17115 | - |
dc.description.abstract | Although L-DOPA (L-3,4-dihydroxyphenylalanine) is widely used as a drug for Parkinson's disease, there are critical drawbacks in the commercial synthetic method such as low conversion rate, poor productivity, and long operational time. In order to overcome these limitations, a novel electroenzymatic system using tyrosinase/carbon nanopowder/polypyrrole composite as a working cathode was reported with the outstanding conversion rate up to 95.9%. However, the productivity was still limited due to a low solubility of the substrate L-tyrosine in aqueous phase. Herein, we demonstrated a novel strategy for enhancing the productivity by employing well-dispersed L-tyrosine as the substrate. When using well-dispersed L-tyrosine, not only the concentration of the substrate was increased to 90.6 gL(-1) in aqueous phase but also the productivity was enhanced up to 15.3 gL(-1) h(-1). We also determined kinetic parameters in the electroenzymatic system and the kinetic results revealed that the outstanding conversion rate was based on the fast electrical reduction of the by-product to L-DOPA. Thus the electroenzymatic synthesis using well-dispersed L-tyrosine can be a potential candidate as a novel process for L-DOPA synthesis. (C) 2013 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | CYCLIC VOLTAMMETRY | - |
dc.subject | KINETICS | - |
dc.title | Novel strategy for enhancing productivity in L-DOPA synthesis: The electroenzymatic approach using well-dispersed L-tyrosine | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Kyungmoon | - |
dc.identifier.doi | 10.1016/j.molcatb.2013.01.027 | - |
dc.identifier.scopusid | 2-s2.0-84875164190 | - |
dc.identifier.wosid | 000316924800013 | - |
dc.identifier.bibliographicCitation | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, v.90, pp.87 - 90 | - |
dc.relation.isPartOf | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | - |
dc.citation.title | JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | - |
dc.citation.volume | 90 | - |
dc.citation.startPage | 87 | - |
dc.citation.endPage | 90 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.subject.keywordPlus | CYCLIC VOLTAMMETRY | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordAuthor | Electroenzymology | - |
dc.subject.keywordAuthor | Well dispersed L-tyrosine | - |
dc.subject.keywordAuthor | L-DOPA | - |
dc.subject.keywordAuthor | Productivity | - |
dc.subject.keywordAuthor | Kinetics | - |
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