Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs
DC Field | Value | Language |
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dc.contributor.author | Song, Doo-Won | - |
dc.contributor.author | Ro, Woong-Bin | - |
dc.contributor.author | Sur, Jung-Hyang | - |
dc.contributor.author | Seung, Byung-Joon | - |
dc.contributor.author | Kang, Hyun-Min | - |
dc.contributor.author | Kim, Jong-Won | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Park, Hee-Myung | - |
dc.date.accessioned | 2021-12-17T02:41:49Z | - |
dc.date.available | 2021-12-17T02:41:49Z | - |
dc.date.created | 2021-12-17 | - |
dc.date.issued | 2021-11 | - |
dc.identifier.issn | 1229-845X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/20994 | - |
dc.description.abstract | Background: Serum-based parameters are considered non-invasive biomarkers for cancer detection. In human studies, insulin-like growth factor-I and II (IGF-I and IGF-II) and insulin-like growth factor binding protein-3 (IGFBP-3) are useful as diagnostic or prognostic markers and potential therapeutic targets. Objectives: This study examined the diagnostic utility of circulating IGF-I, IGF-II, and IGFBP-3 levels in healthy dogs and dogs with tumors. Methods: The serum concentrations of these biomarkers in 86 dogs with tumors were compared with those in 30 healthy dogs using an enzyme-linked immunosorbent assay (ELISA). Results: The ELISA results showed no difference between healthy dogs and dogs with tumors in the serum IGF-II concentrations. On the other hand, there was a significant difference in the circulating IGF-I and IGFBP-3 levels between healthy dogs and dogs with tumors. The concentrations of serum IGF-I (median [interquartile range], 103.4 [59.5-175] ng/mL) in dogs with epithelial tumors were higher than those (58.4 ng/mL [43.5-79.9]) in healthy dogs. Thus, the concentrations of serum IGFBP-3 (43.4 ng/mL [33.2-57.2]) in dogs with malignant mesenchymal tumors were lower than those (60.8 ng/mL [47.6-70.5]) in healthy dogs. Conclusions: The serum IGF-I and IGFBP-3 levels can be used as diagnostic biomarkers in dogs with tumors. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC VETERINARY SCIENCE | - |
dc.subject | GROWTH-FACTOR-I | - |
dc.subject | INSULIN | - |
dc.subject | CANCER | - |
dc.subject | SERUM | - |
dc.subject | HYPOGLYCEMIA | - |
dc.subject | APOPTOSIS | - |
dc.subject | RECEPTOR | - |
dc.subject | PROTEIN | - |
dc.subject | DISEASE | - |
dc.title | Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs | - |
dc.title.alternative | Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, See-Hyoung | - |
dc.identifier.doi | 10.4142/jvs.2021.22.e77 | - |
dc.identifier.scopusid | 2-s2.0-85122489432 | - |
dc.identifier.wosid | 000724288900002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF VETERINARY SCIENCE, v.22, no.6, pp.e77 - 0 | - |
dc.relation.isPartOf | JOURNAL OF VETERINARY SCIENCE | - |
dc.citation.title | JOURNAL OF VETERINARY SCIENCE | - |
dc.citation.volume | 22 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | e77 | - |
dc.citation.endPage | 0 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002781333 | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | GROWTH-FACTOR-I | - |
dc.subject.keywordPlus | INSULIN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | SERUM | - |
dc.subject.keywordPlus | HYPOGLYCEMIA | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordAuthor | Tumors | - |
dc.subject.keywordAuthor | biomarkers | - |
dc.subject.keywordAuthor | insulin-like growth factor | - |
dc.subject.keywordAuthor | insulin-like growth factor binding proteins | - |
dc.subject.keywordAuthor | dogs | - |
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