Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogsEvaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs
- Other Titles
- Evaluation of circulating IGF-I and IGFBP-3 as biomarkers for tumors in dogs
- Authors
- Song, Doo-Won; Ro, Woong-Bin; Sur, Jung-Hyang; Seung, Byung-Joon; Kang, Hyun-Min; Kim, Jong-Won; Park, See-Hyoung; Park, Hee-Myung
- Issue Date
- Nov-2021
- Publisher
- KOREAN SOC VETERINARY SCIENCE
- Keywords
- Tumors; biomarkers; insulin-like growth factor; insulin-like growth factor binding proteins; dogs
- Citation
- JOURNAL OF VETERINARY SCIENCE, v.22, no.6, pp.e77 - 0
- Journal Title
- JOURNAL OF VETERINARY SCIENCE
- Volume
- 22
- Number
- 6
- Start Page
- e77
- End Page
- 0
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/20994
- DOI
- 10.4142/jvs.2021.22.e77
- ISSN
- 1229-845X
- Abstract
- Background: Serum-based parameters are considered non-invasive biomarkers for cancer detection. In human studies, insulin-like growth factor-I and II (IGF-I and IGF-II) and insulin-like growth factor binding protein-3 (IGFBP-3) are useful as diagnostic or prognostic markers and potential therapeutic targets. Objectives: This study examined the diagnostic utility of circulating IGF-I, IGF-II, and IGFBP-3 levels in healthy dogs and dogs with tumors. Methods: The serum concentrations of these biomarkers in 86 dogs with tumors were compared with those in 30 healthy dogs using an enzyme-linked immunosorbent assay (ELISA). Results: The ELISA results showed no difference between healthy dogs and dogs with tumors in the serum IGF-II concentrations. On the other hand, there was a significant difference in the circulating IGF-I and IGFBP-3 levels between healthy dogs and dogs with tumors. The concentrations of serum IGF-I (median [interquartile range], 103.4 [59.5-175] ng/mL) in dogs with epithelial tumors were higher than those (58.4 ng/mL [43.5-79.9]) in healthy dogs. Thus, the concentrations of serum IGFBP-3 (43.4 ng/mL [33.2-57.2]) in dogs with malignant mesenchymal tumors were lower than those (60.8 ng/mL [47.6-70.5]) in healthy dogs. Conclusions: The serum IGF-I and IGFBP-3 levels can be used as diagnostic biomarkers in dogs with tumors.
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Collections - College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles
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