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용매 증발법에 의한 나노 입자 제조 및 아토바스타틴 칼슘의 효과적인 약물전달체로의 응용Atorvastatin calcium-Loaded Polymeric Nanoparticles by Solvent-Evaporation Process and Their Application as a Drug Delivery System
- Other Titles
- Atorvastatin calcium-Loaded Polymeric Nanoparticles by Solvent-Evaporation Process and Their Application as a Drug Delivery System
- Issue Date
- 2010
- Publisher
- 한국생체재료학회
- Keywords
- Atorvastatin calcium; pluroic F-68; nanoparticles; drug delivery system; Atorvastatin calcium; pluroic F-68; nanoparticles; drug delivery system
- Citation
- 생체재료학회지, v.14, no.1, pp.1 - 5
- Journal Title
- 생체재료학회지
- Volume
- 14
- Number
- 1
- Start Page
- 1
- End Page
- 5
- ISSN
- 1226-4601
- Abstract
- Atorvastatin calcium-loaded polymeic nanoparticles were prepared and characterized as a delivery system for hydrophobic drugs. For this purpose, pluronic (poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-68)-based polymeric nanoparticles were prepared by solvent evaporation process. FE-SEM (Field Emission-Scanning Electron Microscopy) was used to observe the morphology of polymeric nanoparticles and electrophoretic light scattering was used to observe the particle size. For the application as an efficient delivery system for atorvastatin calcium, the stability of nanoparticles and release profile was observed in the phosphate buffered solution (pH 7.4).
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Related Researcher
- Kim, Dong Min
- Science & Technology (Department of Nanomaterials Engineering)