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독소루비신이 충진된 pH 민감성 고분자 나노 입자Doxorubicin-Loaded Polymeric Nanoparticles with pH Sensitivity
- Other Titles
- Doxorubicin-Loaded Polymeric Nanoparticles with pH Sensitivity
- Issue Date
- 2009
- Publisher
- 한국생체재료학회
- Keywords
- Doxorubicin hydrochloride; pluronic micelle; pH-sensitive drug delivery; sustained release
- Citation
- 생체재료학회지, v.13, no.4, pp.133 - 137
- Journal Title
- 생체재료학회지
- Volume
- 13
- Number
- 4
- Start Page
- 133
- End Page
- 137
- ISSN
- 1226-4601
- Abstract
- Doxorubicin-loaded polymeic nanoparticles were prepared and characterized as a pH-sensitive drug delivery system. For this purpose, doxorubicin-loaded pluronic (poly (ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymer, F-68) micelles were stabilized with glycol chitosan/heparin composite. FE-SEM (Field Emission-Scanning Electron Microscopy) was used to observe the morphology of polymeric nanoparticles and electrophoretic light scattering was used to observe the particle size. For the application as a pH-sensitive drug delivery, the release profile of doxorubicin was observed in response to environmental pH change.
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Related Researcher
- Kim, Dong Min
- Science & Technology (Department of Nanomaterials Engineering)