pH-sensitive swelling and release behaviors of anionic hydrogels for intelligent drug delivery system
- Authors
- Kim, Bumsang; Shin, Youngchan
- Issue Date
- 15-Sep-2007
- Publisher
- JOHN WILEY & SONS INC
- Keywords
- pH-sensitive; anionic hydrogel; pK(a) of hydrogel; biological on-off switch; intelligent drug delivery system
- Citation
- JOURNAL OF APPLIED POLYMER SCIENCE, v.105, no.6, pp.3656 - 3661
- Journal Title
- JOURNAL OF APPLIED POLYMER SCIENCE
- Volume
- 105
- Number
- 6
- Start Page
- 3656
- End Page
- 3661
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/23539
- DOI
- 10.1002/app.26450
- ISSN
- 0021-8995
- Abstract
- The pH-sensitive swelling and release behaviors of the anionic P(MAA-co-EGMA) hydrogels were investigated as a biological on-off switch for the design of an intelligent drug delivery system triggered by external pH changes. There was a drastic change of the equilibrium weight swelling ratio of P(MAA-co-EGMA) hydrogels at a pH of around 5, which is the pK(a), of poly (methacrylic acid) (PMAA). At a pH below 5, the hydrogels were in a relatively collapsed state but at a pH higher than 5, the hydrogels swelled to a high degree. When the molecular weight of the pendent poly(ethylene glycol) (PEG) of the P(MAA-co-EGMA) increased, the swelling ratio decreased at a pH higher than 5. The pK(a), values of the P(MAA-co-EGMA) hydrogels moved to a higher pH range as the pendent PEG molecular weight increased. When the feed concentration of the crosslinker of the hydrogel increased the swelling ratio of the P(MAA-co-EGMA) hydrogels decreased at a pH higher than 5. In release experiments using Rhodamine B (Rh-B) as a model solute, the P(MAA-co-EGMA) hydrogels showed a pH-sensitive release behavior. At low pH (pH 4.0) a small amount of Rh-B was released while at high pH (PH 6.0) a relatively large amount of Rh-B was released from the hydrogels. (c) 2007 Wiley Periodicals, Inc.
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Collections - College of Engineering > Chemical Engineering Major > 1. Journal Articles
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