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LD50 산출방법에 있어서 수리·통계학적 특성Mathematical and Statistical Characterization of LD50 Estimation
- Other Titles
- Mathematical and Statistical Characterization of LD50 Estimation
- Issue Date
- 2004
- Publisher
- 한국독성학회
- Keywords
- Lethal dose 50% (LD50); Spearman-Karber; Berens-Karber.; Lethal dose 50% (LD50); Spearman-Karber; Berens-Karber.
- Citation
- 한국독성학회지, v.20, no.4, pp.321 - 324
- Journal Title
- 한국독성학회지
- Volume
- 20
- Number
- 4
- Start Page
- 321
- End Page
- 324
- ISSN
- 1976-8257
- Abstract
- Lethal dose 50% (LD50) has been commonly used as a parameter for the estimation of acute toxicity not only in animal experiment, but also in human study. Several methods to estimate LD50 had been introduced, but Spearman-Karber and Berens-Karber method have been widely used due to their relative convenience and accuracy. However, LD50 values estimated from the two methods showed inconsistency and variation depending on the characteristics of mortality data. In this study, the two methods were comparatively investigated in terms of accuracy and stability for the estimation of LD50.
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