The Role of Adiponectin in the Skinopen accessThe Role of Adiponectin in the Skin
- Other Titles
- The Role of Adiponectin in the Skin
- Authors
- Oh Jieun; Lee Yeongyeong; Oh Sae-Woong; Li TianTian; Shin Jiwon; Park See-Hyoung; Lee Jongsung
- Issue Date
- 1-Jan-2022
- Publisher
- 한국응용약물학회
- Keywords
- Adiponectin; Keratinocyte; Melanocyte; Fibroblast; Innate immunity; Adaptive immunity
- Citation
- Biomolecules & Therapeutics, v.30, no.3, pp.221 - 231
- Journal Title
- Biomolecules & Therapeutics
- Volume
- 30
- Number
- 3
- Start Page
- 221
- End Page
- 231
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/27574
- DOI
- 10.4062/biomolther.2021.089
- ISSN
- 1976-9148
- Abstract
- Adiponectin (Ad), a 30 kDa molecule, is an anti-diabetic adipokine; although derived from adipose tissue, it performs numerous activities in various other tissues. It binds to its own receptors, namely adiponectin receptor 1(AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin (CDH13). Ad plays several roles, especially as a regulator. It modulates lipid and glucose metabolism and promotes insulin sensitivity. This demonstrates that Ad has a robust correlation with fat metabolism. Furthermore, although Ad is not in direct contact with other tissues, including the skin, it can be delivered to them by diffusion or secretion via the endocrine system. Recently it has been reported that Ad can impact skin cell biology, underscoring its potential as a therapeutic biomarker of skin diseases. In the present review, we have discussed the association between skin cell biology and Ad. To elaborate further, we described the involvement of Ad in the biology of various types of cells in the skin, such as keratinocytes, fibroblasts, melanocytes, and immune cells. Additionally, we postulated that Ad could be employed as a therapeutic target to maintain skin homeostasis.
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Collections - College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles
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