Time-efficient, high-resolution 3T whole-brain relaxometry using 3D-QALAS with wave-CAIPI readouts
- Authors
- Cho, Jaejin; Gagoski, Borjan; Kim, Tae Hyung; Wang, Fuyixue; Manhard, Mary Kate; Dean, Douglas; Kecskemeti, Steven; Caprihan, Arvind; Lo, Wei-Ching; Splitthoff, Daniel Nico; Liu, Wei; Polak, Daniel; Cauley, Stephen; Setsompop, Kawin; Grant, Patricia Ellen; Bilgic, Berkin
- Issue Date
- Sep-2023
- Publisher
- John Wiley and Sons Inc
- Keywords
- 3D-QALAS; T<sub>1</sub>/T<sub>2</sub>/PD mapping; time-efficient quantitative mapping; wave-CAIPI
- Citation
- Magnetic Resonance in Medicine, v.91, no.2, pp 630 - 639
- Pages
- 10
- Journal Title
- Magnetic Resonance in Medicine
- Volume
- 91
- Number
- 2
- Start Page
- 630
- End Page
- 639
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/32926
- DOI
- 10.1002/mrm.29865
- ISSN
- 0740-3194
1522-2594
- Abstract
- Purpose: Volumetric, high-resolution, quantitative mapping of brain-tissue relaxation properties is hindered by long acquisition times and SNR challenges. This study combines time-efficient wave–controlled aliasing in parallel imaging (wave-CAIPI) readouts with the 3D quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse (3D-QALAS), enabling full-brain quantitative T1, T2, and proton density (PD) maps at 1.15-mm3 isotropic voxels in 3 min. Methods: Wave-CAIPI readouts were embedded in the standard 3D-QALAS encoding scheme, enabling full-brain quantitative parameter maps (T1, T2, and PD) at acceleration factors of R = 3 × 2 with minimum SNR loss due to g-factor penalties. The quantitative parameter maps were estimated using a dictionary-based mapping algorithm incorporating inversion efficiency and B1-field inhomogeneity effects. The parameter maps using the accelerated protocol were quantitatively compared with those obtained from the conventional 3D-QALAS sequence using GRAPPA acceleration of R = 2 in the ISMRM/NIST phantom, and in 10 healthy volunteers. Results: When tested in both the ISMRM/NIST phantom and 10 healthy volunteers, the quantitative maps using the accelerated protocol showed excellent agreement against those obtained from conventional 3D-QALAS at RGRAPPA = 2. Conclusion: Three-dimensional QALAS enhanced with wave-CAIPI readouts enables time-efficient, full-brain quantitative T1, T2, and PD mapping at 1.15 mm3 in 3 min at R = 3 × 2 acceleration. The quantitative maps obtained from the accelerated wave-CAIPI 3D-QALAS protocol showed very similar values to those from the standard 3D-QALAS (R = 2) protocol, alluding to the robustness and reliability of the proposed method. © 2023 International Society for Magnetic Resonance in Medicine.
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