Biodegradable silicon nanoneedles for ocular drug delivery
- Authors
- Park, W.; Nguyen, V.P.; Jeon, Y.; Kim, B.; Li, Y.; Yi, J.; Kim, H.; Leem, J.W.; Kim, Y.L.; Kim, D.R.; Paulus, Y.M.; Lee, C.H.
- Issue Date
- 1-Apr-2022
- Publisher
- American Association for the Advancement of Science
- Citation
- Science Advances, v.8, no.13
- Journal Title
- Science Advances
- Volume
- 8
- Number
- 13
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/32970
- DOI
- 10.1126/sciadv.abn1772
- ISSN
- 2375-2548
2375-2548
- Abstract
- Ocular drug delivery remains a grand challenge due to the complex structure of the eye. Here, we introduce a unique platform of ocular drug delivery through the integration of silicon nanoneedles with a tear-soluble contact lens. The silicon nanoneedles can penetrate into the cornea in a minimally invasive manner and then undergo gradual degradation over the course of months, enabling painless and long-term sustained delivery of ocular drugs. The tear-soluble contact lens can fit a variety of corneal sizes and then quickly dissolve in tear fluid within a minute, enabling an initial burst release of anti-inflammatory drugs. We demonstrated the utility of this platform in effectively treating a chronic ocular disease, such as corneal neovascularization, in a rabbit model without showing a notable side effect over current standard therapies. This platform could also be useful in treating other chronic ocular diseases. © 2022 The Authors
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