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Size-tunable protein-polymer hybrid carrier for cell internalization
- Authors
- Lee, Chaeyeon; Choi, Ji Eun; Park, Gil Yong; Lee, Taeheon; Kim, Jinku; An, Seong Soo A.; Song, Jae Kwang; Paik, Hyun-jong
- Issue Date
- Mar-2018
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Polymer-protein core-shell particle; Functional nanocarrier; One-pot method; Size-control; Endocytosis
- Citation
- REACTIVE & FUNCTIONAL POLYMERS, v.124, pp.72 - 76
- Journal Title
- REACTIVE & FUNCTIONAL POLYMERS
- Volume
- 124
- Start Page
- 72
- End Page
- 76
- ISSN
- 1381-5148
- Abstract
- We describe a polymer-templated protein nanoball (PTPNB) system as an in-situ platform for the preparation of polymer-protein core-shell capsules containing hydrophobic cargos. These structures boast high protein activity through soft immobilization and maintain a consistent protein orientation through a specific interaction between the protein and polymer. We demonstrate the potential of this PTPNB system through bio-conjugation, encapsulation, and size-control of nanoballs in a one-pot process, and furthermore characterize the effects of nanoball size on endocytosis.
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Related Researcher
- Kim, Jin ku
- Science & Technology (Biological and Chemical Engineering)