Arctigenin protects against ultraviolet-A-induced damage to stemness through inhibition of the NF-kappa B/MAPK pathway
- Authors
- Park, See-Hyoung; Cho, Jae Youl; Oh, Sae Woong; Kang, Mingyeong; Lee, Seung Eun; Yoo, Ju Ah; Jung, Kwangseon; Lee, Jienny; Lee, Sang Yeol; Lee, Jongsung
- Issue Date
- 25-Feb-2018
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Arctigenin; Human mesenchymal stem cells; Stemness; UVA damage; HIF
- Citation
- CHEMICO-BIOLOGICAL INTERACTIONS, v.282, pp.63 - 68
- Journal Title
- CHEMICO-BIOLOGICAL INTERACTIONS
- Volume
- 282
- Start Page
- 63
- End Page
- 68
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/3958
- DOI
- 10.1016/j.cbi.2018.01.005
- ISSN
- 0009-2797
- Abstract
- The stemness of stem cells is negatively affected by ultraviolet A (UVA) irradiation. This study was performed to examine the effects of arctigenin on UVA-irradiation-induced damage to the stemness of human mesenchymal stem cells (hMSCs) derived from adipose tissue. The mechanisms of action of arctigenin were also investigated. A BrdU-incorporation assay demonstrated that arctigenin attenuated the UVA-induced reduction of the cellular proliferative potential. Arctigenin also increased the UVA-induced reduction in stemness of hMSCs by upregulating stemness-related genes such as SOX2, OCT4, and NANOG. In addition, the UVA-induced reduction in the mRNA expression level of hypoxia-inducible factor (HIF)-1 alpha was significantly recovered by arctigenin. The antagonizing effect of arctigenin on UVA irradiation was mediated by reduced PGE(2) production through the inhibition of MAPKs (p42/44 MAPK, p38 MAPK, and JNK) and NF-kappa B. Overall, these findings suggest that arctigenin can ameliorate the reduced stemness of hMSCs induced by UVA irradiation. The effects of arctigenin are mediated by PGE2-cAMP signaling-dependent upregulation of HIF-1 alpha. Therefore, arctigenin could be used as an antagonist to attenuate the effects of UVA irradiation.
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Collections - College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles
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