Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-kappa B
DC Field | Value | Language |
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dc.contributor.author | Hwang, Young Sun | - |
dc.contributor.author | Park, See-Hyoung | - |
dc.contributor.author | Kang, Mingyeong | - |
dc.contributor.author | Oh, Sae Woong | - |
dc.contributor.author | Jung, Kwangseon | - |
dc.contributor.author | Park, Yong Seek | - |
dc.contributor.author | Lee, Jongsung | - |
dc.date.available | 2020-07-10T05:18:36Z | - |
dc.date.created | 2020-07-06 | - |
dc.date.issued | 2017-04-19 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/5898 | - |
dc.description.abstract | Ultraviolet A (UVA) irradiation exerts negative effects on stemness and differentiation potential of stem cells. This study aimed to explore the effect of sinapic acid on UVA-irradiation-induced damages to stemness and differentiation potential of human-adipose-tissue-derived mesenchymal stem cells (hAMSCs) and its UVA-antagonist mechanisms. Sinapic acid attenuated UVA-induced reduction in the proliferative potential and stemness by upregulating OCT4, SOX2, and NANOG. In addition, sinapic acid significantly recovered UVA-induced reduction in expression level of hypoxia-inducible factor (HIF)-1 alpha. The antagonist effect of sinapic acid against stemness damage was mediated by reduceing PGE(2) production through inhibition of p38 MAPK and NF-kappa B. Moreover, sinapic acid attenuated UVA-induced reduction in differentiation potential by downregulating the expression of macrophage migration inhibitory factor (MIF) and Kruppel-like factor (KLF) 2 gene while activating AMP-activated protein kinase (AMPK). UVA-induced inhibition of adipogenic differentiation was mediated by reducing MIF production through suppression of NF-kappa B. Taken together, these findings suggest that sinapic acid may ameliorate UVA-irradiation-induced reduced stemness and differentiation potential of hAMSCs. Therefore, sinapic acid might have potential as an antagonist agent to attenuate damages caused by UVA. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | MIGRATION INHIBITORY FACTOR | - |
dc.subject | DELAYED-HYPERSENSITIVITY | - |
dc.subject | SCAVENGING ACTIVITY | - |
dc.subject | BRASSICA-JUNCEA | - |
dc.subject | IN-VITRO | - |
dc.subject | CELLS | - |
dc.subject | PROLIFERATION | - |
dc.subject | HYPOXIA | - |
dc.subject | MIF | - |
dc.subject | ACTIVATION | - |
dc.title | Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-kappa B | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, See-Hyoung | - |
dc.identifier.doi | 10.1038/s41598-017-01089-5 | - |
dc.identifier.scopusid | 2-s2.0-85018347547 | - |
dc.identifier.wosid | 000399530600006 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.7 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | MIGRATION INHIBITORY FACTOR | - |
dc.subject.keywordPlus | DELAYED-HYPERSENSITIVITY | - |
dc.subject.keywordPlus | SCAVENGING ACTIVITY | - |
dc.subject.keywordPlus | BRASSICA-JUNCEA | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | MIF | - |
dc.subject.keywordPlus | ACTIVATION | - |
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