Stemness and differentiation potential-recovery effects of sinapic acid against ultraviolet-A-induced damage through the regulation of p38 MAPK and NF-kappa B
- Authors
- Hwang, Young Sun; Park, See-Hyoung; Kang, Mingyeong; Oh, Sae Woong; Jung, Kwangseon; Park, Yong Seek; Lee, Jongsung
- Issue Date
- 19-Apr-2017
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- SCIENTIFIC REPORTS, v.7
- Journal Title
- SCIENTIFIC REPORTS
- Volume
- 7
- URI
- https://scholarworks.bwise.kr/hongik/handle/2020.sw.hongik/5898
- DOI
- 10.1038/s41598-017-01089-5
- ISSN
- 2045-2322
- Abstract
- Ultraviolet A (UVA) irradiation exerts negative effects on stemness and differentiation potential of stem cells. This study aimed to explore the effect of sinapic acid on UVA-irradiation-induced damages to stemness and differentiation potential of human-adipose-tissue-derived mesenchymal stem cells (hAMSCs) and its UVA-antagonist mechanisms. Sinapic acid attenuated UVA-induced reduction in the proliferative potential and stemness by upregulating OCT4, SOX2, and NANOG. In addition, sinapic acid significantly recovered UVA-induced reduction in expression level of hypoxia-inducible factor (HIF)-1 alpha. The antagonist effect of sinapic acid against stemness damage was mediated by reduceing PGE(2) production through inhibition of p38 MAPK and NF-kappa B. Moreover, sinapic acid attenuated UVA-induced reduction in differentiation potential by downregulating the expression of macrophage migration inhibitory factor (MIF) and Kruppel-like factor (KLF) 2 gene while activating AMP-activated protein kinase (AMPK). UVA-induced inhibition of adipogenic differentiation was mediated by reducing MIF production through suppression of NF-kappa B. Taken together, these findings suggest that sinapic acid may ameliorate UVA-irradiation-induced reduced stemness and differentiation potential of hAMSCs. Therefore, sinapic acid might have potential as an antagonist agent to attenuate damages caused by UVA.
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Collections - College of Science and Technology > Department of Biological and Chemical Engineering > 1. Journal Articles
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