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Parietal-Frontal Pathway Controls Relapse of Fear Memory in a Novel Contextopen access

Authors
Joo, BitnaXu, ShijiePark, HyungjuKim, KipomRah, Jong-CheolKoo, Ja Wook
Issue Date
Jul-2024
Publisher
Elsevier Inc.
Citation
Biological Psychiatry Global Open Science, v.4, no.4
Journal Title
Biological Psychiatry Global Open Science
Volume
4
Number
4
URI
http://scholarworks.bwise.kr/kbri/handle/2023.sw.kbri/1159
DOI
10.1016/j.bpsgos.2024.100315
ISSN
2667-1743
Abstract
Background: Fear responses significantly affect daily life and shape our approach to uncertainty. However, the potential resurgence of fear in unfamiliar situations poses a significant challenge to exposure-based therapies for maladaptive fear responses. Nonetheless, how novel contextual stimuli are associated with the relapse of extinguished fear remains unknown. Methods: Using a context-dependent fear renewal model, the functional circuits and underlying mechanisms of the posterior parietal cortex (PPC) and anterior cingulate cortex (ACC) were investigated using optogenetic, histological, in vivo, and ex vivo electrophysiological and pharmacological techniques. Results: We demonstrated that the PPC-to-ACC pathway governs fear relapse in a novel context. We observed enhanced populational calcium activity in the ACC neurons that received projections from the PPC and increased synaptic activity in the basolateral amygdala–projecting PPC-to-ACC neurons upon renewal in a novel context, where excitatory postsynaptic currents amplitudes increased but inhibitory postsynaptic current amplitudes decreased. In addition, we found that parvalbumin–expressing interneurons controlled novel context-dependent fear renewal, which was blocked by the chronic administration of fluoxetine. Conclusions: Our findings highlight the PPC-to-ACC pathway in mediating the relapse of extinguished fear in novel contexts, thereby contributing significant insights into the intricate neural mechanisms that govern fear renewal.
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연구본부 > 감각·운동시스템 연구그룹 > 1. Journal Articles
연구본부 > 대뇌피질융합연구사업단 > 1. Journal Articles
연구본부 > 신경·혈관 단위체 연구그룹 > 1. Journal Articles
연구본부 > 정서·인지 질환 연구그룹 > 1. Journal Articles
연구전략실 > 인프라구축팀 > 1. Journal Articles

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