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Deciphering signaling pathways in hematopoietic stem cells: the molecular complexity of Myelodysplastic Syndromes (MDS) and leukemic progressionopen access
- Authors
- Casalin, Irene; De Stefano, Alessia; Ceneri, Eleonora; Cappellini, Alessandra; Finelli, Carlo; Curti, Antonio; Paolini, Stefania; Parisi, Sarah; Zannoni, Letizia; Boultwood, Jacqueline; McCubrey, James A.; Suh, Pann-Ghill; Ramazzotti, Giulia; Fiume, Roberta; Ratti, Stefano; Manzoli, Lucia; Cocco, Lucio; Follo, Matilde Y.
- Issue Date
- Jan-2024
- Publisher
- Elsevier Ltd
- Keywords
- Myelodysplastic Syndromes; Acute myeloid leukemia; Phosphoinositide signaling; Epigenetic regulation; Cytokines secretion; Apoptosis
- Citation
- Advances in Biological Regulation, v.91
- Journal Title
- Advances in Biological Regulation
- Volume
- 91
- ISSN
- 2212-4926
2212-4934
- Abstract
- Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis and neoplastic growth. Comprehensive knowledge of these pathways is crucial for the development of innovative therapies that aim to restore normal apoptosis and improve patient outcomes.
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