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Structure-Activity Relationships of Baicalein and its Analogs as Novel TSLP Inhibitors
- Authors
- Bernie Byunghoon Park; Jae Wan Choi; Dawon Park; Doyoung Choi; Jiwon Paek; 김현정; Se-Young Son; Ameeq Ul Mushtaq; Hyeji Shin; Sang Hoon Kim; Yuanyuan Zhou; Taehyeong Lim; Ji Young Park; Ji-Young Baek; Kyul Kim; Hongmok Kwon; Sang-Hyun Son; Ka Young Chung; Hyun-Ja Jeong; Hyung-Min Kim; Yong Woo Jung; Kiho Lee; Ki Yong Lee; Youngjoo Byun; Young Ho Jeon
- Issue Date
- Jun-2019
- Publisher
- Nature Publishing Group
- Citation
- Scientific Reports, v.9, no.1
- Journal Title
- Scientific Reports
- Volume
- 9
- Number
- 1
- ISSN
- 2045-2322
- Abstract
- Thymic stromal lymphopoietin (TSLP) plays an important role in the differentiation and proliferation of Th2 cells, resulting in eosinophilic inflammation and numerous allergic diseases. Baicalein (1), a major component of Scutellaria baicalensis, was found to be the first small molecule to block TSLP signaling pathways. It inhibited effectively eosinophil infiltration in house dust mite-induced and ovalbumin-challenged mouse models. Structure-activity relationship studies identified compound 11a, a biphenyl flavanone analog, as a novel human TSLP inhibitor for the discovery and development of new anti-allergic drugs.
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Collections - 연구본부 > 퇴행성 뇌질환 연구그룹 > 1. Journal Articles
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