Inhibition of Rat Lense Aldose Reductase by Flavonoids from Dandelions
- Authors
- So-Youn Mok; 이설림; 김혜민; 이정민; 이동구; 안영희; Chun-Geon Park; 조은주; 이상현
- Issue Date
- Feb-2011
- Publisher
- 한국생약학회
- Keywords
- Aldose reductase inhibitory activity; Dandelion; Diabetic complications; Luteolin; Luteolin 7-O-glucopyranoside
- Citation
- Natural Product Sciences, v.17, no.2, pp 130 - 134
- Pages
- 5
- Journal Title
- Natural Product Sciences
- Volume
- 17
- Number
- 2
- Start Page
- 130
- End Page
- 134
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/23987
- ISSN
- 1226-3907
- Abstract
- The purpose of this study was to evaluate the therapeutic potential of naturally occurring aldose reductase (AR) inhibitors isolated from Korean native plants. The MeOH extract and stepwise polarity fractions of dandelions were tested on rat lens AR inhibition in vitro. Of these, the EtOAc fractions from the leaves of dandelions (Traxacum coreanum, T. officinale, and T. ohwianum) exhibited an AR inhibitory activity (IC50 values, 2.37, 1.73 and 2.68 mg/ml, respectively). A chromatography of the EtOAc fraction from the leaves of T. coreanum led to the further isolation of two flavonoids identified as luteolin and luteolin 7-O-glucopyranoside. These compounds exhibited strong AR inhibitory activity, with IC50 values of 0.15 and 1.05 mM, respectively. These results suggested that luteolin is a potent AR inhibitor within dandelions and that it could be a useful lead compound in the development of a novel AR inhibitory agent against diabetic complications.
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Collections - Department of Materials Science and Engineering > 1. Journal Articles
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