Multiscale micro-/nanofluidic devices incorporating self-assembled particle membranes for bioanalysis: A review

Abstract

Self-assembled particle membranes (SAPMs), formed by a self-assembly phenomenon of nanoparticles, lend themselves to the facile transport of various ions and molecules, realising the manipulation of bio-samples. Notably, its simple, cost-effective and high throughput fabrication process enables itself to be a unique tool for replacing conventional fabrication methods. This study comprehensively reviews SAPM, from fabrication methods to recent advances in bioanalysis. We firstly categorized the fabrication methods of SAPM, following their working principle: off-chip and on-chip fabrication. Then, we enumerate the application results based on the purpose and the objects' size for manipulation or analysis: ions, molecules, microbes, viruses, cells and particles. As the last statement, we conclude this review and share the author's perspective views on current limitations and the required efforts for solving them. We hope this review article will provide an appropriate guideline for many researchers, thereby widening the spectrum of applications of SAPMs in the future.(c) 2023 Elsevier B.V. All rights reserved.