Daily Amperometric Monitoring of Immunoglobulin E in a Mouse Whole Blood: Model of Ovalbumin Induced AsthmaDaily Amperometric Monitoring of Immunoglobulin E in a Mouse Whole Blood: Model of Ovalbumin Induced Asthma
- Other Titles
- Daily Amperometric Monitoring of Immunoglobulin E in a Mouse Whole Blood: Model of Ovalbumin Induced Asthma
- Authors
- Ju Kyung Lee; 김상희; 윤성훈
- Issue Date
- Feb-2022
- Publisher
- 한국전기화학회
- Keywords
- Electrochemical Amperometry (EA); Screen Printed Electrode (SPE); Ovalbumin (OVA); Immunoglobulin E (IgE); Allergic asthma
- Citation
- 전기화학회지, v.25, no.1, pp 13 - 21
- Pages
- 9
- Journal Title
- 전기화학회지
- Volume
- 25
- Number
- 1
- Start Page
- 13
- End Page
- 21
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/26274
- DOI
- 10.5229/JKES.2022.25.1.13
- ISSN
- 1229-1935
2288-9000
- Abstract
- There is an increasing interest in monitoring of specific biomarker for determining progression of a disease or efficacy of a treatment. Conventional method for quantification of specific biomarkers as enzyme linked immunosorbent assay (ELISA) has high material costs, long incubation periods, requires large volume of samples and involves special instruments, which necessitates clinical samples to be sent to a lab. This paper reports on the development of an electrochemical biosensor to measure total immunoglobulin E (IgE), a marker of asthma disease that varies with age, gender, and disease in concentrations from 0.3-1000 ng/mL with consuming 20 μL volume of whole blood sample. The sensor provides rapid, accurate, easy, point-of-care measurement of IgE, also, sequential monitoring of total IgE with ovalbumin (OVA) induced mice is another application of sensor. Taken together, these results provide an alternative way for detection of biomarkers in whole blood with low volumes and long-term ex-vivo assessments for understanding the progression of a disease.
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