Zn- doped MnFe2O4 nanoparticles for magnetic hyperthermia and their cytotoxicity study in normal and cancer cell lines

Abstract

To improve magnetic hyperthermia for the treatment of cancer, we prepared Mn1_xZnxFe2O4 (x = 0.1, 0.3, 0.4, & 0.5) magnetic nanoparticles (NPs) using the solvothermal reflux method. The preparation of NPs single phase was confirmed by X-ray diffraction (XRD) investigation. The prepared sample's magnetic properties were greatly improved by the addition of Zn, increasing its magnetization value. The specific loss power (SLP) values in DI water were used to assess the performance of the colloids. Zn0.1Mn0.9Fe2O4 NPs displayed the highest SLP value among the samples, at 1 mg/mL concentration (107.79 W/g) in an alternating magnetic field (AMF) of 35.2 kA/ m and 316 kHz. This proved how effectively they could produce heat for magnetic hyperthermia therapy. Through cell cytotoxicity analysis, the cytotoxicity of the Zn-doped MnFe2O4 NPs was evaluated, and the results showed high biocompatibility and negligible cytotoxicity. This shows that the NPs are appropriate for biomedical applications, particularly in the treatment of cancer with magnetic hyperthermia. The better magnetic charac-teristics and effective heat generation for hyperthermia treatment were obtained through the synthesis of Zn-doped MnFe2O4 NPs. The NPs also showed great biocompatibility, making them viable options for biomedical applications, particularly in the treatment of cancer.