Mesoporous Silica-Layered Gold Nanorod Core@Silver Shell Nanostructures for Intracellular SERS Imaging and Phototherapyopen access
- Authors
- Seo, Sun-Hwa; Joe, Ara; Han, Hyo-Won; Manivasagan, Panchanathan; Jang, Eue-Soon
- Issue Date
- Jan-2024
- Publisher
- MDPI
- Keywords
- gold nanorod core; silver shell; cancer; phototherapy; SERS imaging
- Citation
- PHARMACEUTICS, v.16, no.1
- Journal Title
- PHARMACEUTICS
- Volume
- 16
- Number
- 1
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/26604
- DOI
- 10.3390/pharmaceutics16010137
- ISSN
- 1999-4923
1999-4923
- Abstract
- Precision diagnosis-guided efficient treatment is crucial to extending the lives of cancer patients. The integration of surface-enhanced Raman scattering (SERS) imaging and phototherapy into a single nanoplatform has been considered a more accurate diagnosis and treatment strategy for cancer nanotheranostics. Herein, we constructed a new type of mesoporous silica-layered gold nanorod core@silver shell nanostructures loaded with methylene blue (GNR@Ag@mSiO(2)-MB) as a multifunctional nanotheranostic agent for intracellular SERS imaging and phototherapy. The synthesized GNR@Ag@mSiO(2)-MB nanostructures possessed a uniform core-shell structure, strong near-infrared (NIR) absorbance, photothermal conversion efficiency (65%), dye loading ability, SERS signal, and Raman stability under phototherapy conditions. Under single 785 nm NIR laser irradiation, the intracellular GNR@Ag@mSiO(2)-MB nanostructures were dramatically decreased to <9%, which showed excellent photothermal and photodynamic effects toward cancer cell killing, indicating that the combination of photothermal therapy (PTT) and photodynamic therapy (PDT) of the GNR@Ag@mSiO(2)-MB nanostructures could greatly enhance the therapeutic efficacy of cancer cell death. GNR@Ag@mSiO(2)-MB nanostructures demonstrated a strong Raman signal at 450 and 502 cm(-1), corresponding to the delta(C-N-C) mode, suggesting that the Raman bands of GNR@Ag@mSiO(2)-MB nanostructures were more efficient to detect CT-26 cell SERS imaging with high specificity. Our results indicate that GNR@Ag@mSiO(2)-MB nanostructures offer an excellent multifunctional nanotheranostic platform for SERS imaging and synergistic anticancer phototherapy in the future.
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