Triphenylphosphonium-Functionalized Gold Nanorod/Zinc Oxide Core-Shell Nanocomposites for Mitochondrial-Targeted Phototherapyopen access
- Authors
- Joe, Ara; Han, Hyo-Won; Lim, Yu-Ra; Manivasagan, Panchanathan; Jang, Eue-Soon
- Issue Date
- Feb-2024
- Publisher
- MDPI
- Keywords
- gold nanorods; zinc oxide; triphenylphosphonium; cancer; phototherapy
- Citation
- PHARMACEUTICS, v.16, no.2
- Journal Title
- PHARMACEUTICS
- Volume
- 16
- Number
- 2
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/28568
- DOI
- 10.3390/pharmaceutics16020284
- ISSN
- 1999-4923
- Abstract
- Phototherapies, such as photothermal therapy (PTT) and photodynamic therapy (PDT), combined with novel all-in-one light-responsive nanocomposites have recently emerged as new therapeutic modalities for the treatment of cancer. Herein, we developed novel all-in-one triphenylphosphonium-functionalized gold nanorod/zinc oxide core-shell nanocomposites (CTPP-GNR@ZnO) for mitochondrial-targeted PTT/PDT owing to their good biocompatibility, tunable and high optical absorption, photothermal conversion efficiency, highest reactive oxygen species (ROS) generation, and high mitochondrial-targeting capability. Under laser irradiation of 780 nm, the CTPP-GNR@ZnO core-shell nanocomposites effectively produced heat in addition to generating ROS to induce cell death, implying a synergistic effect of mild PTT and PDT in combating cancer. Notably, the in vitro PTT/PDT effect of CTPP-GNR@ZnO core-shell nanocomposites exhibited effective cell ablation (95%) and induced significant intracellular ROS after the 780 nm laser irradiation for 50 min, indicating that CTPP in CTPP-GNR@ZnO core-shell nanocomposites can specifically target the mitochondria of CT-26 cells, as well as generate heat and ROS to completely kill cancer cells. Overall, this light-responsive nanocomposite-based phototherapy provides a new approach for cancer synergistic therapy.
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Collections - Department of Applied Chemistry > 1. Journal Articles
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