Fabrication of poly(xylitol-citrate-sebacate) and strontium-doped mesoporous bioactive glass scaffold for tissue engineering application

Abstract

In this study, strontium-doped mesoporous bioactive glass nanoparticles (Sr-MBGNs) were incorporated into a poly(xylitol-citrate-sebacate) (PXCS) matrix using solution mixing techniques. The resulting composites, including PXCS, PXCS/1.5% Sr-MBGNs, PXCS/3% Sr-MBGNs, and PXCS/5% Sr-MBGNs, were characterized for biomedical applications using FTIR, DSC, and x-ray diffraction analyses. High-resolution scanning electron microscopy (HRSEM) and a universal testing machine were employed to investigate the structure, morphology, and mechanical properties of the polymer and its nanocomposites. Our findings indicate that the introduction of polymer and its nanocomposites minimally affects the glass transition and crystallinity. The observed decrease in glass transition temperature with increasing Sr-MBGNs content suggests a plasticizing effect. These results are consistent with previous studies. Additionally, in vitro studies were conducted to evaluate antibacterial properties, VERO cell line proliferation, degradation, and swelling percentage of the scaffolds. Metal ions release behavior was assessed using inductively coupled plasma atomic emission spectrometry (ICP-AES) Furthermore, the drug loading and release of curcumin from PXCS/5% Sr-MBGNs and PXCS/Sr-MBGNs nanocomposite scaffolds were investigated at varying pH levels (pH: 5.5, 6.8, and 7.4). Both PXCS/5% Sr-MBGNs and PXCS/5% Sr-MBGNs scaffolds demonstrated enhanced biological properties, highlighting their potential for use in bone regeneration approaches.