Fabrication and Characterization of 3D Printed PGA Scaffolds Immobilized with BMP-2 for Bone Tissue Engineering
- Authors
- Lee, Jiyoung; Ko, Yunjeh; Chung, Ho Yun; Kwon, Oh Hyeong
- Issue Date
- Jul-2024
- Publisher
- POLYMER SOC KOREA
- Keywords
- poly(glycolic acid); scaffold; bone morphogenetic protein-2; 3D printing; bone tissue engineering
- Citation
- POLYMER-KOREA, v.48, no.4, pp 426 - 439
- Pages
- 14
- Journal Title
- POLYMER-KOREA
- Volume
- 48
- Number
- 4
- Start Page
- 426
- End Page
- 439
- URI
- https://scholarworks.bwise.kr/kumoh/handle/2020.sw.kumoh/28857
- DOI
- 10.7317/pk.2024.48.4.426
- ISSN
- 0379-153X
2234-8077
- Abstract
- This study focused on immobilizing bone morphogenetic protein-2 (BMP-2) onto a 3D-printed poly(glycolic acid) (PGA) scaffold to develop a biodegradable scaffold for continuous bone formation stimulation in bone tissue engineering. BMP-2 immobilization was achieved using the UV irradiation method and confirmed through ATR-FTIR and XPS analyses. The scaffold's structure, hydrolytic degradation behavior, and in vitro cell viability were analyzed. Furthermore, the BMP-2 release behavior and calcification performance of the scaffold were evaluated for osteogenic tissue engineering applications. Results from in vivo animal model experiments and histological analyses demonstrated that the BMP-2 immobilized PGA scaffold exhibited superior bone tissue regeneration ability compared to the control group. And, It suggests potential as a scaffold in bone tissue engineering.
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