Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E-2 Generation in LPS-stimulated RAW264.7 Cells
DC Field | Value | Language |
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dc.contributor.author | Jung, Yu Yeon | - |
dc.contributor.author | Hong, Jin Tae | - |
dc.contributor.author | Han, Sang Bae | - |
dc.contributor.author | Park, Young Hyun | - |
dc.contributor.author | Son, Dong Ju | - |
dc.date.accessioned | 2021-08-11T19:25:15Z | - |
dc.date.available | 2021-08-11T19:25:15Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.issn | 2092-6685 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10109 | - |
dc.description.abstract | Inflammation is the basis of severe acute and chronic diseases. This study investigated the anti-inflammatory property of a crude methanol extract (MeOH-ex) and the solvent fractions of Ixeris dentata Nakai (IDN) in LPS-stimulated murine macrophage-like cell line RAW264.7. Here, we showed that the ethyl acetate fraction (EtOAc-fr) had the most potent inhibitory activity on LPS-induced nitric oxide (NO) production among the tested samples, i.e., IDN MeOH-ex and the three different solvent fractions (chloroform, n-hexane, and EtOAc). We further found that the EtOAc-fr significantly inhibited LPS-induced prostaglandin PGE2 (PGE2) generation in RAW264.7 cells. Furthermore, the treatment with EtOAc-fr effectively suppressed the expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2). These results suggest that the EtOAc-fr of IDN MeOH-ex exhibits an anti-inflammatory activity in vitro by inhibiting LPS-induced NO production and PGE2 generation via suppression of iNOS and COX-2 expression. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한면역학회 | - |
dc.title | Effect of Ixeris dentata Nakai Extract on Nitric Oxide Production and Prostaglandin E-2 Generation in LPS-stimulated RAW264.7 Cells | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4110/in.2015.15.6.325 | - |
dc.identifier.wosid | 000421279500007 | - |
dc.identifier.bibliographicCitation | Immune Network, v.15, no.6, pp 325 - 330 | - |
dc.citation.title | Immune Network | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 330 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002067462 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordAuthor | Ixeris dentate Nakai | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Prostaglandin E2 | - |
dc.subject.keywordAuthor | iNOS | - |
dc.subject.keywordAuthor | COX-2 | - |
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