Detailed Information
Cited 0 time in 
Cited 9 time in 
Cited 9 time in
Metadata Downloads
Laser Photocoagulation Induces Transduction of Retinal Pigment Epithelial Cells by Intravitreally Administered Adeno-Associated Viral Vectors
- Issue Date
- 1-Oct-2015
- Publisher
- Mary Ann Liebert Inc.
- Keywords
- Laser Photocoagulation Induces Transduction; RetinalPigment Epithelial Cells; AdministeredAdeno-Associated Viral Vectors
- Citation
- Human gene therapy methods, v.26, no.5, pp 159 - 161
- Pages
- 3
- Journal Title
- Human gene therapy methods
- Volume
- 26
- Number
- 5
- Start Page
- 159
- End Page
- 161
- ISSN
- 1946-6536
1946-6544
- Abstract
- Retinal transduction by intravitreally administered adeno-associated viral (AAV) vector is previously known to be extremely limited to the neural retina except AAV2 capsid type. Recently, we showed that prior laser photocoagulation enhances retinal transduction of intravitreally administered AAV vectors, including the outer retina and retinal pigment epithelium (RPE). Here, by performing short-pulse laser pretreatment on the mouse retina, we demonstrate RPE cells transduced by three different capsid types of AAV vectors, AAV2, AAV5, and AAV8, using RPE wholemounts. For all capsid types, laser pretreatment effectively induced the transduction of RPE cells in and around the laser site.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Ophthalmology > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Related Researcher
- Park, Tae Kwann
- College of Medicine (Department of Ophthalmology)