Long-term outcome of endoscopic and surgical resection for foregut neuroendocrine tumors
- Authors
- Jung, Hee Jae; Hong, Su Jin; Han, Jae Pil; Kim, Hyun Su; Jeong, Gui-Ae; Cho, Gyu-Seok; Kim, Hee Kyoung; Ko, Bong Min; Lee, Moon Sung
- Issue Date
- Oct-2015
- Publisher
- Blackwell Pub. Asia
- Keywords
- endoscopic resection; foregut; neuroendocrine tumors; long-term outcome; neoplasm metastasis; surgery
- Citation
- Journal of Digestive Diseases, v.16, no.10, pp 595 - 600
- Pages
- 6
- Journal Title
- Journal of Digestive Diseases
- Volume
- 16
- Number
- 10
- Start Page
- 595
- End Page
- 600
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10237
- DOI
- 10.1111/1751-2980.12279
- ISSN
- 1751-2972
1751-2980
- Abstract
- OBJECTIVE: Endoscopic resection (ER) of foregut neuroendocrine tumors (NETs) is increasingly performed instead of surgery. This study aimed to compare the long-term therapeutic outcomes of ER and surgical resection (SR) for foregut NETs. METHODS: From 2002 to 2012, a total of 49 patients with histologically confirmed foregut NETs were treated by ER (n = 33) and SR (n = 16). The clinicopathological characteristics and therapeutic outcomes were evaluated. RESULTS: Of the 33 patients who underwent ER [ endoscopic mucosal resection (n = 26), endoscopic mucosal dissection(n = 7)], 32 were diagnosed as NET-G1 and NET-G2, and the other as neuroendocrine carcinoma (NEC). Of the 16 patients who underwent SR, 10 were diagnosed as NET-G1, 2 as NET-G2 and 4 as NEC. The median tumor size was significantly smaller in the ER group compared with the SR group (7 mm vs 19 mm, P = 0.001). In almost all patients treated with ER (32/33), NET invasion was limited to the mucosa and submucosa. Non-curative resections were observed in 24.2% of the patients in the ER group (8/33) and 25.0% in the SR group (4/16). No recurrence occurred in NET cases with positive resection margins by ER. However, all cases of non-curative resection with lymphatic invasion (one in the ER group and four in the SR group) developed liver metastasis during the follow-up despite complete resection, and all these five patients has histologically confirmed NECs. CONCLUSION: NET patients treated by ER may have a good prognosis if the tumor size is small and histologically low grade without lymphatic invasion.
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- Appears in
Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of General Surgery > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
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