Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype
DC Field | Value | Language |
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dc.contributor.author | Jang, J. E. | - |
dc.contributor.author | Min, Y. H. | - |
dc.contributor.author | Yoon, J. | - |
dc.contributor.author | Kim, I. | - |
dc.contributor.author | Lee, J-H | - |
dc.contributor.author | Jung, C. W. | - |
dc.contributor.author | Shin, H-J | - |
dc.contributor.author | Lee, W. S. | - |
dc.contributor.author | Lee, J. H. | - |
dc.contributor.author | Hong, D-S | - |
dc.contributor.author | Kim, H-J | - |
dc.contributor.author | Kim, H-J | - |
dc.contributor.author | Park, S. | - |
dc.contributor.author | Lee, K-H | - |
dc.contributor.author | Jang, J. H. | - |
dc.contributor.author | Chung, J. S. | - |
dc.contributor.author | Lee, S. M. | - |
dc.contributor.author | Park, J. | - |
dc.contributor.author | Park, S. K. | - |
dc.contributor.author | Ahn, J-S | - |
dc.contributor.author | Min, W-S | - |
dc.contributor.author | Cheong, J-W | - |
dc.date.accessioned | 2021-08-11T19:44:13Z | - |
dc.date.available | 2021-08-11T19:44:13Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 2044-5385 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10265 | - |
dc.description.abstract | Monosomal karyotype (MK) defined by either >= 2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), >= 10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Nature Publishing Group | - |
dc.title | Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1038/bcj.2015.84 | - |
dc.identifier.scopusid | 2-s2.0-84989352624 | - |
dc.identifier.wosid | 000368920300008 | - |
dc.identifier.bibliographicCitation | Blood Cancer Journal, v.5 | - |
dc.citation.title | Blood Cancer Journal | - |
dc.citation.volume | 5 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.subject.keywordPlus | STEM-CELL TRANSPLANTATION | - |
dc.subject.keywordPlus | COMPLEX ABERRANT KARYOTYPE | - |
dc.subject.keywordPlus | PROGNOSTIC IMPACT | - |
dc.subject.keywordPlus | POOR-PROGNOSIS | - |
dc.subject.keywordPlus | MYELODYSPLASTIC SYNDROME | - |
dc.subject.keywordPlus | POSTREMISSION THERAPY | - |
dc.subject.keywordPlus | TP53 MUTATION | - |
dc.subject.keywordPlus | DELETION | - |
dc.subject.keywordPlus | ADULT | - |
dc.subject.keywordPlus | SUBGROUP | - |
dc.subject.keywordAuthor | 혈액종양내과학 | - |
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