Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotype
- Authors
- Jang, J. E.; Min, Y. H.; Yoon, J.; Kim, I.; Lee, J-H; Jung, C. W.; Shin, H-J; Lee, W. S.; Lee, J. H.; Hong, D-S; Kim, H-J; Kim, H-J; Park, S.; Lee, K-H; Jang, J. H.; Chung, J. S.; Lee, S. M.; Park, J.; Park, S. K.; Ahn, J-S; Min, W-S; Cheong, J-W
- Issue Date
- Oct-2015
- Publisher
- Nature Publishing Group
- Keywords
- 혈액종양내과학
- Citation
- Blood Cancer Journal, v.5
- Journal Title
- Blood Cancer Journal
- Volume
- 5
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10265
- DOI
- 10.1038/bcj.2015.84
- ISSN
- 2044-5385
- Abstract
- Monosomal karyotype (MK) defined by either >= 2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), >= 10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated.
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