Development of Thyroid-Associated Ophthalmopathy in Patients Who Underwent Total Thyroidectomy
- Authors
- Jang, Sun Young; Lee, Ka Hyun; Oh, Jong Rok; Kim, Bo Yeon; Yoon, Jin Sook
- Issue Date
- 1-Sep-2015
- Publisher
- 연세대학교의과대학
- Keywords
- Total thyroidectomy; thyroid-associated orbitopathy; TSH receptor autoantibody; thyroid cancer; thyroid benign mass
- Citation
- Yonsei Medical Journal, v.56, no.5, pp 1389 - 1394
- Pages
- 6
- Journal Title
- Yonsei Medical Journal
- Volume
- 56
- Number
- 5
- Start Page
- 1389
- End Page
- 1394
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10281
- DOI
- 10.3349/ymj.2015.56.5.1389
- ISSN
- 0513-5796
1976-2437
- Abstract
- Purpose: To report clinical characteristics of thyroid-associated ophthalmopathy (TAO) in patients who previously underwent total thyroidectomy for thyroid cancer or a benign mass of the thyroid. Materials and Methods: Of the patients who were diagnosed with TAO from March 2008 to March 2012, we performed a retrospective chart review on those who had undergone total thyroidectomy for thyroid cancer or a benign mass of the thyroid before the occurrence of ophthalmopathy. Results: Of the 206 patients diagnosed with TAO, seven (3.4%) met the inclusion criteria. The mean age of the subjects was 47.4 years, and all were female. Six patients were diagnosed with papillary thyroid cancer, and one was diagnosed with a benign mass. The duration between total thyroidectomy and onset of TAO ranged from 3-120 months (median 48 months). Ophthalmic manifestations varied among cases. Except for the patient who was diagnosed with a benign mass, all patients showed hyperthyroid status and were under Synthroid hormone treatment at the time of TAO development. Five of these six patients had positive levels of thyroid-stimulating hormone (TSH) receptor autoantibodies. Conclusion: TAO rarely develops after total thyroidectomy, and the mechanism of TAO occurrence is unclear. However, most patients showed abnormalities in thyroid function and TSH receptor autoantibodies.
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- Appears in
Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Ophthalmology > 1. Journal Articles
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