Analysis of RAS mutation and PAX8/PPAR gamma rearrangements in follicular-derived thyroid neoplasms in a Korean population: frequency and ultrasound findings
- Authors
- Jeong, S. H.; Hong, H. S.; Kwak, J. J.; Lee, E. H.
- Issue Date
- Aug-2015
- Publisher
- Editrice Kurtis srl
- Keywords
- Thyroid cancer; Follicular; PAX8-PPAR gamma fusion protein; Human genes; RAS mutations
- Citation
- Journal of Endocrinological Investigation, v.38, no.8, pp 849 - 857
- Pages
- 9
- Journal Title
- Journal of Endocrinological Investigation
- Volume
- 38
- Number
- 8
- Start Page
- 849
- End Page
- 857
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10421
- DOI
- 10.1007/s40618-015-0311-x
- ISSN
- 0391-4097
1720-8386
- Abstract
- Objective To investigate the frequency and ultrasonography (US) findings of RAS mutations and PAX8/PPAR gamma rearrangements between follicular thyroid adenomas (FTAs) and follicular thyroid carcinomas (FTCs) in a Korean population. Methods RAS mutations and PAX8/PPAR gamma rearrangements in 56 FTAs and 35 FTCs were analyzed. We also analyzed the US findings of FTCs and FTAs. Results 16 nodules of 35 FTCs (45.7 %) and 19 nodules of 56 FTAs (33.9 %) harbored RAS mutations. Three FTCs and three FTAs showed two point mutations simultaneously. K-RAS codon 12-13 (n = 6, 31.6 %), N-RAS codon 61 (n = 5, 26.3 %), H-RAS codon 61 (n = 4, 21.1 %), K-RAS codon 61 (n = 3, 15.8 %), and N-RAS codon 12-13 (n = 1, 5.3 %) were found in FTCs, and N-RAS codon 61 (n = 10, 45 %), K-RAS codon 12-13 (n = 5, 22.7 %), H-RAS codon 61 (n = 5, 22.7 %), K-RAS codon 61 (n = 1, 4.5 %), and N-RAS codon 12-13 (n = 1, 4.5 %) were observed in FTAs. 4 of 56 (7.1 %) FTAs and 1 of 35 (2.9 %) FTCs represented PAX8/PPAR gamma rearrangements, respectively (P = 0.645). The absence of a hypoechoic rim (P = 0.021) and presence of calcifications (P = 0.049) were significantly associated with FTCs compared with FTAs. Conclusions RAS mutation frequency targeting the Korean population showed a 45.7 % in FTCs and 35.7 % in FTAs, and PAX8/PPAR gamma rearrangements were more frequently showed in FTAs. K-RAS codon 12-13 was the most common RAS mutation in FTCs, whereas N-RAS codon 61 was more frequent in FTAs. The presence of calcifications and absence of a hypoechoic rim showed more frequently in FTCs.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Pathology > 1. Journal Articles
- College of Medicine > Department of Radiology > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10421)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.