Development of a genetic marker set to diagnose aspirin-exacerbated respiratory disease in a genome-wide association study
- Authors
- Chang, H. S.; Shin, S. W.; Lee, T. H.; Bae, D. J.; Park, J. S.; Kim, Y. H.; Uh, S. T.; Choi, B. W.; Kim, M. K.; Choi, I. S.; Park, B. L.; Shin, H. D.; Park, C. S.
- Issue Date
- Aug-2015
- Publisher
- Nature Publishing Group
- Keywords
- 호흡기내과
- Citation
- Pharmacogenomics Journal, v.15, no.4, pp 316 - 321
- Pages
- 6
- Journal Title
- Pharmacogenomics Journal
- Volume
- 15
- Number
- 4
- Start Page
- 316
- End Page
- 321
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10444
- DOI
- 10.1038/tpj.2014.78
- ISSN
- 1470-269X
1473-1150
- Abstract
- We developed a genetic marker set of single nucleotide polymorphisms (SNPs) by summing risk scores of 14 SNPs showing a significant association with aspirin-exacerbated respiratory disease (AERD) from our previous 660 W genome-wide association data. The summed scores were higher in the AERD than in the aspirin-tolerant asthma (ATA) group (P = 8.58 x 10(-37)), and were correlated with the percent decrease in forced expiratory volume in 1 s after aspirin challenge (r(2) = 0.150, P = 5.84 x 10(-30)). The area under the curve of the scores for AERD in the receiver operating characteristic curve was 0.821. The best cutoff value of the summed risk scores was 1.01328 (P = 1.38 x 10(-32)). The sensitivity and specificity of the best scores were 64.7% and 85.0%, respectively, with 42.1% positive and 93.4% negative predictive values. The summed risk score may be used as a genetic marker with good discriminative power for distinguishing AERD from ATA.
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Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Department of Internal Medicine > 1. Journal Articles
- College of Medicine > Soonchunhyang Institute of Medicine > 1. Journal Articles
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