Expression of p27 and Jun activation domain-binding protein 1 in endometriosis
- Authors
- Kim, Tae-Hee; Lee, Hae-Hyeog; Chung, Soo-Ho; Park, Junsik; Lee, Arum
- Issue Date
- Aug-2015
- Publisher
- Springer Verlag
- Keywords
- p27; Jab1; Endometriosis
- Citation
- Archives of Gynecology and Obstetrics, v.292, no.2, pp 377 - 381
- Pages
- 5
- Journal Title
- Archives of Gynecology and Obstetrics
- Volume
- 292
- Number
- 2
- Start Page
- 377
- End Page
- 381
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10454
- DOI
- 10.1007/s00404-015-3642-0
- ISSN
- 0932-0067
1432-0711
- Abstract
- The goal of this study was to investigate differential expression of the cell cycle signaling proteins p27 and Jun activation domain-binding protein 1 (Jab1) in benign ovarian cysts of patients with endometriosis compared to controls. Ovarian tissues of 26 endometriosis and 28 non-endometriosis patients were used to evaluate expression of p27 and Jab1 by immunohistochemistry. There are no differences in clinical characteristics between the endometriosis and non-endometriosis group. In the endometriosis group, CD10, Jab1 and p27 were positive in 50, 48.3 and 57.7 % of cases, respectively, compared to 14.3, 17.9 and 50 %, respectively, in the non-endometriosis group. Jab1 and p27 were positive in 69.2 and 84.6 %, respectively, of the definite endometriosis cases. These results demonstrate that Jab1 expression was increased in endometriosis, while p27 expression was similar in the endometriosis and non-endometriosis groups.
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Collections - College of Medicine > Department of Obstetrics and Gynecology > 1. Journal Articles
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