Protective effects of PEP-1-Catalase on stress-induced cellular toxicity and MPTP-induced Parkinson's disease
- Authors
- Eom, Seon Ae; Kim, Dae Won; Shin, Min Jea; Ahn, Eun Hee; Chung, Seok Young; Sohn, Eun Jeong; Jo, Hyo Sang; Jeon, Su-Jeong; Kim, Duk-Soo; Kwon, Hyeok Yil; Cho, Sung-Woo; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Choi, Soo Young
- Issue Date
- 31-Jul-2015
- Publisher
- 생화학분자생물학회
- Keywords
- Parkinson's disease; ROS; PEP-1-Catalase; Protein therapy; Dopaminergic neuron
- Citation
- BMB Reports, v.48, no.7, pp 395 - 400
- Pages
- 6
- Journal Title
- BMB Reports
- Volume
- 48
- Number
- 7
- Start Page
- 395
- End Page
- 400
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10455
- DOI
- 10.5483/BMBRep.2015.48.7.197
- ISSN
- 1976-6696
1976-670X
- Abstract
- Parkinson's disease (PD) is a neurodegenerative disability caused by a decrease of dopaminergic neurons in the substantia nigra (SN). Although the etiology of PD is not clear, oxidative stress is believed to lead to PD. Catalase is antioxidant enzyme which plays an active role in cells as a reactive oxygen species (ROS) scavenger. Thus, we investigated whether PEP-1-Catalase protects against 1-methyl-4-phenylpyridinium (MPP+) induced SH-SY5Y neuronal cell death and in a 1-methyl-4-phenyl-1,2,3,6-trtrahydropyridine (MPTP) induced PD animal model. PEP-1-Catalase transduced into SH-SY5Y cells significantly protecting them against MPP+-induced death by decreasing ROS and regulating cellular survival signals including Akt, Bax, Bcl-2, and p38. Immunohistochemical analysis showed that transduced PEP-1-Catalase markedly protected against neuronal cell death in the SN in the PD animal model. Our results indicate that PEP-1-Catalase may have potential as a therapeutic agent for PD and other oxidative stress related diseases.
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Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
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