Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-kappa B and MAPK activation in macrophages and TPA-induced ear edema in mice
DC Field | Value | Language |
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dc.contributor.author | Kim, Young Nam | - |
dc.contributor.author | Kim, Dae Won | - |
dc.contributor.author | Jo, Hyo Sang | - |
dc.contributor.author | Shin, Min Jea | - |
dc.contributor.author | Ahn, Eun Hee | - |
dc.contributor.author | Ryu, Eun Ji | - |
dc.contributor.author | Yong, Ji In | - |
dc.contributor.author | Cha, Hyun Ju | - |
dc.contributor.author | Kim, Sang Jin | - |
dc.contributor.author | Yeo, Hyeon Ji | - |
dc.contributor.author | Youn, Jong Kyu | - |
dc.contributor.author | Hwang, Jae Hyeok | - |
dc.contributor.author | Jeong, Ji-Heon | - |
dc.contributor.author | Kim, Duk-Soo | - |
dc.contributor.author | Cho, Sung-Woo | - |
dc.contributor.author | Park, Jinseu | - |
dc.contributor.author | Eum, Won Sik | - |
dc.contributor.author | Choi, Soo Young | - |
dc.date.accessioned | 2021-08-11T19:46:17Z | - |
dc.date.available | 2021-08-11T19:46:17Z | - |
dc.date.issued | 2015-07-15 | - |
dc.identifier.issn | 0041-008X | - |
dc.identifier.issn | 1096-0333 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10461 | - |
dc.description.abstract | Human carbonyl reductase 1 (CBR1) plays a crucial role in cell survival and protects against oxidative stress response. However, its anti-inflammatory effects are not yet clearly understood. In this study, we examined whether CBR1 protects against inflammatory responses in macrophages and mice using a Tat-CBR1 protein which is able to penetrate into cells. The results revealed that purified Tat-CBR1 protein efficiently transduced into Raw 264.7 cells and inhibited lipopolysaccharide (LPS)-induced cyclooxygenase-2 (COX-2), nitric oxide (NO) and prostaglandin E-2 (PGE(2)) expression levels. In addition, Tat-CBR1 protein leads to decreased proinflammatory cytokine expression through suppression of nuclear transcription factor-kappaB (NF-kappa B) and mitogen activated protein kinase (MAPK) activation. Furthermore, Tat-CBR1 protein inhibited inflammatory responses in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin inflammation when applied topically. These findings indicate that Tat-CBR1 protein has anti-inflammatory properties in vitro and in vivo through inhibition of NF-kappa B and MAPK activation, suggesting that Tat-CBR1 protein may have potential as a therapeutic agent against inflammatory diseases. (C) 2015 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | Tat-CBR1 inhibits inflammatory responses through the suppressions of NF-kappa B and MAPK activation in macrophages and TPA-induced ear edema in mice | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.taap.2015.03.020 | - |
dc.identifier.scopusid | 2-s2.0-84930277324 | - |
dc.identifier.wosid | 000356119600006 | - |
dc.identifier.bibliographicCitation | Toxicology and Applied Pharmacology, v.286, no.2, pp 124 - 134 | - |
dc.citation.title | Toxicology and Applied Pharmacology | - |
dc.citation.volume | 286 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 124 | - |
dc.citation.endPage | 134 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | OXIDATIVE-STRESS | - |
dc.subject.keywordPlus | CARBONYL REDUCTASE | - |
dc.subject.keywordPlus | PROTEIN TRANSDUCTION | - |
dc.subject.keywordPlus | MOUSE SKIN | - |
dc.subject.keywordPlus | COX-2 EXPRESSION | - |
dc.subject.keywordPlus | CELL-DEATH | - |
dc.subject.keywordPlus | ORNITHINE-DECARBOXYLASE | - |
dc.subject.keywordPlus | ALVEOLAR MACROPHAGES | - |
dc.subject.keywordPlus | MURINE MACROPHAGES | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Skin inflammation | - |
dc.subject.keywordAuthor | Oxidative stress | - |
dc.subject.keywordAuthor | Tat-CBR1 | - |
dc.subject.keywordAuthor | Protein therapy | - |
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