Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma
DC Field | Value | Language |
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dc.contributor.author | Choi, In Ho | - |
dc.contributor.author | Kim, Dong Won | - |
dc.contributor.author | Ha, Sang Yun | - |
dc.contributor.author | Choi, Yoon-La | - |
dc.contributor.author | Lee, Hee Jeong | - |
dc.contributor.author | Han, Joungho | - |
dc.date.accessioned | 2021-08-11T19:46:57Z | - |
dc.date.available | 2021-08-11T19:46:57Z | - |
dc.date.issued | 2015-07 | - |
dc.identifier.issn | 2383-7837 | - |
dc.identifier.issn | 2383-7845 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10526 | - |
dc.description.abstract | Background: Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment advantage has been observed in patients harboring the EML4/ALK translocation. However, using ALK-fluorescence in situ hybridization (FISH) as the standard method has demerits such as high cost, a time-consuming process, dependency on interpretation skill, and tissue preparation. We analyzed the histologic findings which could complement the limitation of ALK-FISH test for pulmonary adenocarcinoma. Methods: Two hundred five cases of ALK-positive and 101 of ALK-negative pulmonary adenocarcinoma from January 2007 to May 2013 were enrolled in this study. The histologic findings and ALK immunohistochemistry results were reviewed and compared with the results of ALK-FISH and EGFR/KRAS mutation status. Results: Acinar, cribriform, and solid growth patterns, extracellular and intracellular mucin production, and presence of signet-ring-cell element, and psammoma body were significantly more often present in ALK-positive cancer. In addition, the presence of goblet cell-like cells and presence of nuclear inclusion and groove resembling papillary thyroid carcinoma were common in the ALK-positive group. Conclusions: The above histologic parameters can be helpful in predicting ALK rearranged pulmonary adenocarcinoma, leading to rapid FISH analysis and timely treatment. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한병리학회 | - |
dc.title | Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4132/jptm.2015.05.13 | - |
dc.identifier.scopusid | 2-s2.0-84942941495 | - |
dc.identifier.wosid | 000218425500004 | - |
dc.identifier.bibliographicCitation | Journal of Pathology and Translational Medicine, v.49, no.4, pp 310 - 317 | - |
dc.citation.title | Journal of Pathology and Translational Medicine | - |
dc.citation.volume | 49 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 310 | - |
dc.citation.endPage | 317 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002013163 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pathology | - |
dc.relation.journalWebOfScienceCategory | Pathology | - |
dc.subject.keywordAuthor | Lung | - |
dc.subject.keywordAuthor | Adenocarcinoma | - |
dc.subject.keywordAuthor | Anaplastic large cell lymphoma kinase | - |
dc.subject.keywordAuthor | Anaplastic lymphoma kinase | - |
dc.subject.keywordAuthor | In situ hybridization | - |
dc.subject.keywordAuthor | fluorescence | - |
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