Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma
- Authors
- Choi, In Ho; Kim, Dong Won; Ha, Sang Yun; Choi, Yoon-La; Lee, Hee Jeong; Han, Joungho
- Issue Date
- Jul-2015
- Publisher
- 대한병리학회
- Keywords
- Lung; Adenocarcinoma; Anaplastic large cell lymphoma kinase; Anaplastic lymphoma kinase; In situ hybridization; fluorescence
- Citation
- Journal of Pathology and Translational Medicine, v.49, no.4, pp 310 - 317
- Pages
- 8
- Journal Title
- Journal of Pathology and Translational Medicine
- Volume
- 49
- Number
- 4
- Start Page
- 310
- End Page
- 317
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/10526
- DOI
- 10.4132/jptm.2015.05.13
- ISSN
- 2383-7837
2383-7845
- Abstract
- Background: Since 2007 when anaplastic lymphoma kinase (ALK) rearrangements were discovered in non-small cell lung cancer, the ALK gene has received attention due to ALK-targeted therapy, and a notable treatment advantage has been observed in patients harboring the EML4/ALK translocation. However, using ALK-fluorescence in situ hybridization (FISH) as the standard method has demerits such as high cost, a time-consuming process, dependency on interpretation skill, and tissue preparation. We analyzed the histologic findings which could complement the limitation of ALK-FISH test for pulmonary adenocarcinoma. Methods: Two hundred five cases of ALK-positive and 101 of ALK-negative pulmonary adenocarcinoma from January 2007 to May 2013 were enrolled in this study. The histologic findings and ALK immunohistochemistry results were reviewed and compared with the results of ALK-FISH and EGFR/KRAS mutation status. Results: Acinar, cribriform, and solid growth patterns, extracellular and intracellular mucin production, and presence of signet-ring-cell element, and psammoma body were significantly more often present in ALK-positive cancer. In addition, the presence of goblet cell-like cells and presence of nuclear inclusion and groove resembling papillary thyroid carcinoma were common in the ALK-positive group. Conclusions: The above histologic parameters can be helpful in predicting ALK rearranged pulmonary adenocarcinoma, leading to rapid FISH analysis and timely treatment.
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